目的：探讨枫蓼肠胃康联合5⁃氟尿嘧啶给药对结肠炎相关性结肠癌小鼠的治疗作用及机制。方法：建立结肠炎相关性结肠癌小鼠模型，经枫蓼肠胃康和5⁃氟尿嘧啶给药后，观察小鼠的行为及活动情况；HE染色观察小鼠结肠组织的病理学变化；采用Western blot检测小鼠结肠组织在IL⁃6/STAT3通路相关蛋白的表达。结果：联合给药组小鼠的存活率明显提高，且小鼠肠壁增厚及间质炎症情况明显减轻。Western blot结果显示经造模后小鼠结肠组织中P⁃STAT3及IL⁃6的表达水平明显升高，联合给药后，抑制了IL⁃6/STAT3通路中Cyclin D1、CDK4和Bcl⁃2蛋白表达，上调了Bax的表达（P<0.05）。结论：枫蓼肠胃康联合5⁃氟尿嘧啶可抑制IL⁃6/STAT3通路来发挥对结肠炎相关性结肠癌的抑制作用。

Objective：To investigate the therapeutic effects and mechanisms of Feng⁃Liao⁃Chang⁃Wei⁃Kang combined with 5⁃fluorouracil administration in mice with colitis⁃associated colon cancer.Methods：To establish a colitis⁃associated colon cancer mouse model and observe the behavior and activity of mice after Feng⁃Liao⁃Chang⁃Wei⁃Kang and 5⁃fluorouracil administration； HE staining was used to observe the pathological changes of mouse colonic tissue； Western blot was used to detect the expression of mouse colon tissue in IL⁃6/STAT3 pathway⁃related proteins.Results：The survival rate of mice in the co⁃administered group was significantly increased， and the intestinal wall thickening and interstitial inflammation of mice were significantly reduced.Western blot results showed that the expression levels of P⁃STAT3 and IL⁃6 were significantly increased in the colonic tissue of mice after modeling， and the combined administration inhibited the expression of Cyclin D1， CDK4 and Bcl⁃2 protein in the IL⁃6/STAT3 pathway and upregulated the expression of Bax（P<0.05）.Conclusion：Feng⁃Liao⁃Chang⁃Wei⁃Kang combined with 5⁃fluorouracil inhibits IL⁃6/STAT3 pathway to exert inhibition of colitis⁃associated colon cancer inhibition of colitis⁃associated colon cancer.

国家自然科学基金（81760674）； 海南省研究生创新科研课题（Hys2020?371）