姓名：朱海珍

医学博士，教授，

博士生和硕士生导师，博士后合作导师

联系方式：hzzhu@muhn.edu.cn  

基本信息：

主要从事病毒学、免疫学、肿瘤学、分子生物学和细胞生物学领域的教学和科研工作，聚焦于感染免疫和肿瘤免疫方面的研究。主持承担国家自然科学基金重点项目、科技部国家科技重大专项项目等科研项目。在Cell Reports、Nature Communications、PNAS、Gastroenterology、Hepatology、Cellular & Molecular Immunology、PLoS Pathogens、Journal of Virology、The Journal of Immunology、Bioinformatics、JACS等学术刊物上发表110余篇学术论文，获得11项国内外发明专利。获得3项省级科技奖励。

招聘信息：

本实验室长期招聘博士后（全年），并长期招收基础医学、生物学方向的硕士研究生和博士研究生。

研究领域：

主要从事病毒学、免疫学、肿瘤学、分子生物学和细胞生物学领域的科研工作，聚焦于感染免疫和肿瘤免疫方面的研究，具体研究内容包括病毒与宿主的相互作用、肿瘤细胞信号传导与免疫调节机制、病毒的免疫逃逸机制，以及病毒性疾病和恶性肿瘤的药物与疫苗的研发。

部分论文目录:

(1) Tian R, Yang D, Xu B, Deng R, Xue B, Wang L, Li H, Liu Q, Wang X, Tang S, Wan M, Pei H, Zhu H*. Establishment of cell culture model and humanized mouse model of chronic hepatitis B virus infection. Microbiology Spectrum 2024; 12(1):e0274523.

(2) Liu Q, Chen S, Tian R, Xue B, Li H, Guo M, Liu S, Yan M, You R, Wang L, Yang D, Wan M, Zhu H*. 3β-hydroxysteroid-Δ24 reductase dampens anti-viral innate immune responses by targeting K27 ubiquitination of MAVS and STING. Journal of Virology 2023; 97(12):e0151323.

(3) Li H, Liu S, Feng Q, Deng R, Wang J, Wang X, Tian R, Xu Y, Chen S, Liu Q, Wang L, Li X, Wan M, Peng Y, Tang S, Xue B*, Zhu H*. Regulation of PKR-dependent RNA translation inhibition by TRIM21 upon virus infection or other stress. PLoS Pathogens 2023; 19(6):e1011443.

(4) Wang L, Deng R, Chen S, Tian R, Guo M, Chen Z, Zhang Y, Li H, Liu Q, Tang S*, Zhu H*. Carboxypeptidase A4 negatively regulates HGS-ETR1/2-induced pyroptosis by forming a positive feedback loop with the AKT signaling pathway. Cell Death & Disease 2023; 14(12):793.

(5) Yang D, Tian R, Deng R, Xue B, Liu S, Wang L, Li H, Liu Q, Zhu H*. The dual functions of KDM7A in HBV replication and immune microenvironment. Microbiology Spectrum 2023; e0164123.

(6) Xue B, Li H, Liu S, Feng Q, Xu Y, Deng R, Chen S, Wang J, Li X, Wan M, Tang, S, Zhu H*. The redox cycling of STAT2 maintains innate immune homeostasis. Cell Reports 2022; 40(7):111215.

(7) Wang C, Li X, Xue B, Yu C, Wang L, Deng R, Li H, Chen Z, Zhang Y, Fan S, Zuo C, Sun H, Zhu H*, Wang J*, Tang S*. RasGRP1 promotes the acute inflammatory responses and restricts inflammation-associated cancer cell growth. Nature Communications 2022; 13:7001.

(8) Guo M, Cao W, Chen S, Tian R, Xue B, Wang L, Liu Q, Deng R, Wang X, Wang Z, Zhang Y, Yang D, Li G, Zuo C, Tang S, Zhu H*. TRIM21 regulates virus-induced cell pyroptosis through polyubiquitination of ISG12a. The Journal of Immunology 2022; 209(10):1987-1998.

(9) Chen S, Huang X, Xie Q, Liu Q, Zhu H*.The role of long noncoding RNA BST2-2 in the innate immune response to viral infection. Journal of Virology  2022; 96(7): e00207-22.

(10) Xu Y, Yang Q, Xue B, Wang X, Tian R, Wang X, Deng R, Wang L, Chen S, Wang C, Chen J, You R, Liu Q, Li H, Wang J, Li X, Liu S, Yang D,  Zhu H*. Heat shock-binding protein 21 regulates the innate immune response to viral infection. Journal of Virology 2022; 96(7):e00001-22.

(11) Chen S, Liu Q, Zhang L, Ma J, Xue B, Li H, Deng R, Guo M, Xu Y, Tian R, Wang J, Cao W, Yang Q, Wang L, Li X, Liu S, Yang D, Zhu H*. The role of REC8 in the innate immune response to viral infection. Journal of Virology 2022; 96(6): e02175-21.

(12) Deng R, Zuo C, Li Y, Xue B, Xun Z, Guo Y, Wang X, Xu Y, Tian R, Chen S, Wang J, Liu Q, Chen J, Wang J, Huang X, Li H, Guo M, Wang X, Yang M, Wu Z, Ma J, Hu J, Li G, Tang S, Tu Z, Ji H, Zhu H*. Innate immune effector ISG12a promotes cancer immunity through suppressing canonical Wnt/β-catenin signaling pathway. Cellular & Molecular Immunology 2020; 17(11):1163-1179.

(13) Wang J, Li H, Xue B, Deng R, Huang X, Xu Y, Chen S, Tian R, Wang X, Xun Z, Sang M, Zhu H*. IRF1 promotes the innate immune response to viral infection through enhancing the activation of IRF3. Journal of Virology 2020;94(22):e01231-20.