ࡱ>  bjbj## 2A_A_P=dd    LV T 9b """"#$T$,9999999>@^9E%##%%9""[9000%""z80%9000"11-1f8q9091A}/A"1"1A610%%0%%%%%99e0"%%%9%%%%A%%%%%%%%%dX : [^{N  *NNOo`Y T Ly f[SI{ Y T4TefN LyYec f[SZSX Ye~S 1983t^9g-1987t^7g NSN^'Yf[u}Tyf[f[b uirf[ f[X 1987t^9g-1990t^7g NwmN'Yf[;Sf[bS Nwm,{N;Sy'Yf[ MQuf[ UxX 1997t^9g-2001t^12g _KQ(e]'Yf[M.D.[_hLvu-N_, Lvuuirf[ ZSX ;N]\O~S ,gN/fwmWS;Sy'Yf[pN$vVExvz-N_ (ICAC) vyrXYec0UxX/ZSXTZSXT[^ NSybyrXN[0VVhQLRvICACKNMR, SN O)R O'Yf[RTR!h;Sf[|v~uYecLMO0(WdkKNMR,,gNf(WV;Sf[-N_xvz@b0TX+Y('Yf[;Sf[b0R]'Yf[eёq\R!h<\eY+Y?Qz;Sb0R]'Yf[/OKQ)RR!hr^~ހ-N_bNhQLb|QLvYeyL v^bNyxyv#NPI)0(WYt^vxvz]\O-N ,gNv[[]~ccN\ uu!jWg^0@mTr^~ހxvz0RP[uirf[TWVI{N|R8^ĉTryrvb/g0,gNb g0N[v[[{t~ dN N T*N'`vRt^f[lNAm0(W,gNvc[ N Y TZSXT](WVb-NVvؚI{Ye:ggbNRtYecTYecI{YeLNS;Sf[boRbI{͑LMO0 f[/gbg;Ncvw萧~N N Shvؚ4ls^eI{ ,gNxvzWmvNڀ΀r^~ހ0@mr^~ހ0}v@u0r^~ހTpI{MRlyf[0\O:N,{N\O0\ObqQ T\O N(W 0Cell 00 0Blood 00 0J Clin Invest. 00 0Nature Communications 00 0Molecular Cancer 00 0Leukemia 00 0Molecular Therapy 00 0Stem Cell Reports 00 0Stem Cell Translational Medicine 00 0Cell Research 00 0Oncogene 0I{VEw Tf[/gg R NShNN|Rxvze0,gNvxvz!kc:yN\[NSO @|~ b_c$Ov~ހTRP[uirf[:g6R, dk͑'YSsf 0CELL 0Bg_ :N\bEeN _wNf[/gLug'YtQ0,gN;NcNYy1uVVzkSuxvzbNIH I{yx:ggDRvxvzyv v^Y!kSSRNIHvċ[YXTO NSV;Sf[xvzOMRC TNrRybWёOvċ[]\O0 eSh(*\O) 1. Yanwen Ge, Mei Hong, Yu Zhang, Jiachen Wang, Lei Li, Hongkai Zhu, Yue Sheng, Wen-Shu Wu*, Zhonghi Zhang*. miR-30e-5p regulates leukemia stem cell self-renewal through the Cyb561/ROS signaling pathway. Haematologica, 2024, 109(2):411-421. 2. Pingping Wang, Qianqian Kang, Wen-Shu Wu*, Liangyou Rui*. Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice. Cell Rep., 2024, 43(3): 113875 3. Min-Hyun Kim, Yuan Li, Qiantao Zheng, Lin Jiang, Martin G. Myers Jr., Wen-Shu Wu, and Liangyou Rui. LepRb+ cellspecific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice. J Clin Invest., 2023, 133(4):e156722. doi: 10.1172/JCI156722. 4. Yan Liu, Haiyan Lin, Lin Jiang, Qingsen Shang, Lei Yin, Jiandie D. Lin, Wen-Shu Wu*, and Liangyou Rui*. Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes. J Clin Invest. 2020, Jun 1;130(6):2992-3004. doi: 10.1172/JCI128073. 5. Pei Zhu, Chunping Zhang, Yongxing Gao, Furen Wu, Yalu Zhou, and Wen-Shu Wu*. The Transcription Factor Slug Represses p16Ink4a and Regulates Murine Muscle Stem Cell aging. Nature Communications, 2019, 10(1):2568 6. Zhonghui Zhang,Lei Li,Chen Wu,Guoshu Yin,Pei Zhu,Yalu Zhou,Yuanfan Hong,Hongyu Ni,Zhijian Qian,Wen-Shu Wu*. Inhibition of Slug Effectively Targets Leukemia Stem Cells via the Slc13a3/ROS Signaling Pathway. Leukemia, 2019, Sept. 06. PMID: 31492896 7. Pei Zhu, Furen Wu, Jeffrey Mosenson, Hongmei Zhang, Tong-Chuan He, and Wen-Shu Wu*. CRISPR/Cas9-mediated Genome Editing Correct Dystrophin Mutation in Skeletal Muscle Stem Cells in a Mouse Model of Muscle Dystrophy. Molecular Therapy -Nucleic Acids, 2017 Jun 16; 7:31-41. 8. Pei Zhu, Yalu Zhou, Furen Wu, Yuanfan Hong, Xin Wang, Gajendra Shekhawat, Jeffrey Mosenson, and Wen-Shu Wu*. Selective Expansion of Skeletal Muscle Stem Cells from Bulk Muscle Cells in Soft 3D Fibrin Gel. Stem Cell Translational Medicine, 2017 May; 6(5):1412-1423. 9. ZZhang, PZhu, YZhou, YSheng, YHong, DXiang, ZQian, JMosenson and Wen-Shu Wu*. A novel slug-containing negative feedback loop regulates SCF/c-Kit-mediated hematopoietic stem cell self-renewal. Leukemia, 2016 Aug 26. doi: 10.1038/leu.2016.201. [Epub ahead of print] 10.  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Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States. Cell Stem Cell, 2016, 16:30153-3. 11. Hou Y, Li W, Sheng Y, Li L, Huang Y, Zhang Z, Zhu T, Peace D, Quigley JG, Wu W, Zhao YY, Qian Z. The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells. Nature Immunology, 2015, 16(8):810-8. 12. Berna Uygur, Katrina Abramo, Evgenia Leikina, Calvin Vary, Lucy Liaw, and Wen-Shu Wu*. SLUG is a Direct Transcriptional Repressor of PTEN Tumor Suppressor. Prostate, 2015, 75(9):907-16. 13. Zhonghui Zhang, Yuanfan Hong, Di Xiang, Pei Zhu, Elise Wu, Wen Li, Jeffrey Mosenson, and Wen-Shu Wu*. MicroRNA-302/367 Cluster Governs hESC Self-renewal by Dually Regulating Cell Cycle and Apoptosis Pathways. Stem Cell Reports, 2015, 4(4):645-657. 14. Zhonghui Zhang, Elise Wu, Zhijian Qian, and Wen-Shu Wu*. A multicolor panel of TALE-KRAB based transcriptional repressor vectors enabling knockdown of multiple gene targets. 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Ming Ming, Sheng Wang, Wenshu Wu, Vitalyi Senyuk, Michelle M. Le Beau, Giuseppina Nucifora, and Zhijian Qian. Activation of Wnt/(-Catenin Protein Signaling Induces Mitochondria-mediated Apoptosis in Hematopoietic Progenitor Cells. Journal of Biological Chemistry, 2012, 287 (27), 2268322690. 20. Bai H, Chen K, Gao YX, Arzigian M, Xie YL, Malcosky C, Yang YG, Wu WS, Wang ZZ. Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal. Stem Cell Research, 2012, 8(1): 26-37. 21. Berna Uygur and Wen-Shu Wu*. SLUG promotes prostate cancer cell migration and invasion via CXCR4/CXCL12 axis. Molecular Cancer, 2011, 10:139. 22. Zhonghui Zhang, Yongxing Gao, Albert Gordon, Zack Wang, Zhijian Qian, and Wen-Shu Wu*. Efficient generation of fully reprogrammed human iPS cells via polycistronic retroviral vector and a new cocktail of chemical compounds. PLoS One, 2011, 6(10): e26592. 23. Kang Chen, Hao Bai, Melanie Arzigian, Yong-Xing Gao, Jing Bao, Wen-Shu Wu, Wei-Feng Shen, Zack Wang. Endothelial cells regulate cardiomyocyte development from embryonic stem cells. Journal of Cellular Biochemistry, 2010, 111 (1), 29-39. 24. Jun Liu, Berna Uyger, Zhonghui Zhang, Lijian Shao, Diana Romero, Calvin Vary, Qiang Ding, and Wen-Shu Wu*. Slug Inhibits Proliferation of Human Prostate Cancer Cells via Downregulation of Cyclin D1 Expression. Prostate, 2010, 70(16):1768-77. 25. Lijian Shao, Yan Sun, Zhonghhui Zhang, Wei Feng, Yongxing Gao, Zailong Cai, Zack Z. Wang, A. Thomas Look, and Wen-Shu Wu*. (2010). Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. Blood, 115 (23), 4707-4714. 26.  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The Cover: "Slug Represses Puma to Antagonize Apoptosis" Cell, Nov.18, 2005 Previews: "Slugging It out: Fine Tuning the p53-PUMA Death Connection" Cell, 123, 545-548, 2005 Research Highlights: "Slug beats Puma" Nature, Vol. 438, 398-399, 2005 Research Highlights: "Taming Puma" Nature Reviews Cancer, Vol. 6, 1, 2006 News and Reports: "Slug ging It Out Until the End" Hematologist, Vol. 3, 7, 2006 News and Commentary: "Clues from worms: a Slug at Puma promotes the survival of blood progenitors" Cell Death and Differentiation 13, 2006 (March 17) 33. Takeshi Inukai, Toshiya Inaba, Jinjun Dang, Ryoko Kuribara, Keiya Ozawa, Atsushi Miyajima, WenShu Wu, A. Thomas Look, Yojiro Arinobu, Hiromi Iwasaki, Koichi Akashi, Keiko Kagami, Kumiko Goi, Kanji Sugita, and Shinpei Nakazawa. TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors. Blood, Vol. 105, 2005 34. 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HYPERLINK "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&term=%22Shearer+DW%22%5BAuthor%5D" \o "Click to search for citations by this author." Shearer DW,  HYPERLINK "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&term=%22Wu+WS%22%5BAuthor%5D" \o "Click to search for citations by this author." Wu WS. Sodium/Proton Antiporter in the Euryhaline Crab Carcinus Maenas: Molecular Cloning, Expression and Tissure Distribution. J. Exp. 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