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NBSTJG&>#fO>)4@2n%MGjnᅩ("㥝ϏcZ\v{h\mڼs׏©؝n8j]r )]8_4> ߽~0:瞱-ݾȡ&3xvA dgt8A?W\^M8fh*x{5{p-j1Ԭ" +O)`P9ۏU BR29^=Lno1B~P՝xZy83qls|)Sc]k^H^B#(bH8|1H.dpVI cou>նă)W@k>8?Z(+?f^{- Pe/⢭lV#(wZ('s?鯤d([)3iVtGya6 牢VKqB\q㓶5֊+̱֬bzuףB>Q]tgS≶Dohڛ5ؒ6sQEYqq.tf f_QTc`I7tQEL~'t,/ )lO{ ( PjSKSKS3~%,x ,x t<i:< $eh)<T| [^{N  *NNOo`Y T Ly f[SI{ -Y wmWS;Sf[yf[b/wmWS;Sy'Yf[Yec0ZSXu[^0eQ V[wmYؚB\!kNMb Rt^CSN 2016 V[ NNR ybReQNMb2024 0-Nq\'Yf[ ~vNR 2015 0^Nw s_lNMbR 2016 -YYecgRNЏ(uؚϑWV~Km^s^SxvzNSWSؚSv`'`$vvW ONh‰W OS_ v^~T$vWV~T4N^utOo`SsevvTluel t[$vluovRP[:gt0xvzeTSb$vW ONh‰W OS_N[MQu8:g6R0eWbLvoirs^Sg^S[{ T$vluo:g6RI{0vMRxvz͑pSb`$Ǐ$vWV~f[Th‰WV~f[c:y$vMQu8:g6R0a$t[$vluovRP[:g6RNSvTluh_ir0b$Џ(u N T$v!jWxvzvTTSu-Nvo:gtSvQ4N^lSxvz0;NcV[6qWё͑pVET\Oyv1y b N2ySyb͑'YxSyvP[ v^(W-NVbLvOSOI{10YO*Nf[/gYXTONYXT0vMRShSCIe70YO{ vQ-NN,{N\Ob\O+TqQ T (WNature Genetics(2), Cancer Cell(2), Cancer Discovery(2), J Clin Invest(3), Leukemia(2), Genes and Development, PNAS(2), Cancer Research(3), GUT, Mol CancerI{VEw TBg_ NSh35{e0;`N_!kpeǏ5700!k0H-index:320 Ye~S 2007.07-2012.05 eRaWVz'Yf[;Sf[b$vuirf[NNZSXf[MO 1999.09-2002.07 S'Yf[u}Tyf[f[buirSf[NRP[uirf[NNUxXf[MO 1995.09-1999.07 S'Yf[u}Tyf[f[buirb/gNNf[Xf[MO ;N]\O~S 2024t^-N wmWS;Sf[yf[b/wmWS;Sy'Yf[ Yec/ZSXu[^ 2020t^-N eRaWVzLvu-N_|QLxvzXT 2015-2024 -Nq\'Yf[$v-N_/NSWS$vf[V[͑p[[Yec/ZSXu[^ 2013.07-2015.10 eRaWVzLvuxvz-N_$vh‰WV~xvz[bNؚ~xvzXT 2012.07-2013.06 eRaWWV~xvzb$v*NSOSluxvz[bNZSXT 2004.01-2007.07eRaWWV~xvzb$vRP[ot[[bNؚ~[XT 2002.08-2004.01 ~e nfёeeRaWLvu$vh‰W Of[[[bN[XT f[/gbg;Ncvw萧~N N Shvؚ4ls^eI{ яNt^Nh'`e 1. 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Hong JH, Yong CH, Heng HL, Chan JY, Lau MC, Chen J, Lee JY, Lim AH, Li Z, Guan P, Chu PL, Boot A, Ng SR, Yao X, Wee FYT, Lim JCT, Liu W, Wang P, Xiao R, Zeng X, Sun Y, Koh J, Kwek XY, Ng CCY, Klanrit P, Zhang Y, Lai J, Tai DWM, Pairojkul C, Dima S, Popescu I, Hsieh SY, Yu MC, Yeong J, Kongpetch S, Jusakul A, Loilome W, Tan P, Tan J#, Teh BT#. Integrative Multi-Omics Enhancer Activity Profiling Identifies Therapeutic Vulnerabilities in Cholangiocarcinoma of Different Etiologies, Gut 2023 Nov 24:gutjnl-2023-330483 (qQ T\O IF:24.5) 8. Yu Z, Deng P, Chen Y, Lin D, Liu S, Hong J, Guan P, Chen J, Zhong ME, Chen J, Chen X, Sun Y, Wang Y, Wang P, Cai Z, Chan JY, Huang Y, Xiao R, Guo Y, Zeng X, Wang W, Zou Y, Yu Q, Lan P, Teh BT, Wu X, Tan J. Pharmacological modulation of RB1 activity mitigates resistance to neoadjuvant chemotherapy in locally advanced rectal cancer, Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2304619121 (\O IF=12.5) 8. Liu L, Deng P, Liu S, Hong JH, Xiao R, Guan P, Wang Y, Wang P, Gao J, Chen J, Sun Y, Chen J, Mai HQ,Tan J. Enhancer remodeling activates NOTCH3 signaling to confer chemoresistance in advanced nasopharyngeal carcinoma, Cell Death Dis. 2023 Aug 10;14(8):513 (\O, IF9.6) 9. Chen J, Hong JH, Huang Y, Liu S, Yin J, Deng P, Sun Y, Yu Z, Zeng X, Xiao R, Chan JY, Guan P, Wang Y, Wang P, Liu L, Wen S, Yu Q, Ong CK, Teh BT, Xiong Y, Tan J. EZH2 mediated metabolic rewiring promotes tumor growth independently of histone methyltransferase activity in ovarian cancer. Mol Cancer. 2023 May 20;22(1):85. (\O, IF37) 10. Chen J, Zuo Z, Gao Y, Yao X, Guan P, Wang Y, Li Z, Liu Z, Hong JH, Deng P, Chan JY, Cheah DMZ, Lim J, Chai KXY, Chia BKH, Pang JWL, Koh J, Huang D, He H, Sun Y, Liu L, Liu S, Huang Y, Wang X, You H, Saraf SA, Grigoropoulos NF, Li X, Bei J, Kang T, Lim ST, Teh BT, Huang H, Ong CK, Tan J. Aberrant JAK-STAT signaling-mediated chromatin remodeling impairs the sensitivity of NK/T-cell lymphoma to chidamide. Clin Epigenetics 2023 Feb 6;15(1) (\O IF: 7.28) 11. Wang Y, Zhou W, Chen J, Chen J, Deng P, Chen H, Sun Y, Yu Z, Pang D, Liu L, Wang P, Hong JH, Teh BT, Huang H, Li W, Yi Z, Lim ST, Chen Y, Ong CK, Liu M, Tan J. Preclinical characterization of WB737, a potent and selective STAT3 inhibitor, in natural killer/T-cell lymphoma, MedComm (2020). 2023 Jun 16;4(4) (\O IF:9.9) 12. Deng P, Wang Z, Chen J, Liu S, Yao X, Liu S, Liu L, Yu Z, Huang Y, Xiong Z, Xiao R, Gao J, Liang W, Chen J, Liu H, Hong JH, Chan JY, Guan P, Chen J, Wang Y, Yin J, Li J, Zheng M, Zhang C, Zhou P, Kang T, Teh BT, Yu Q, Zuo Z, Jiang Q, Liu J, Xiong Y, Xia X, Tan J. RAD21 amplification epigenetically suppresses interferon signaling to promote immune evasion in ovarian cancer. J Clin Invest. 2022 Oct 6:e159628. doi: 10.1172/JCI159628 (\O IF:19.456) 13. Sun Y, Gao Y, Chen J, Huang L, Deng P, Chen J, Chai KXY, Hong JH, Chan JY, He H, Wang Y, Cheah D, Lim JQ, Chia BKH, Huang D, Liu L, Liu S, Wang X, Teng Y, Pang D, Grigoropoulos NF, Teh BT, Yu Q, Lim ST, Li W, Ong CK, Huang H, Tan J. CREBBP cooperates with the cell cycle machinery to attenuate chidamide sensitivity in relapsed/refractory diffuse large B-cell lymphoma. Cancer Lett. 2021 Sep2:S0304-3835(21)00438-9.doi:10.1016/j.canlet.2021.09.002. PMID: 34481935 (\O IF:8.6) 14. Zhaoliang Yu*, Peng Deng*, Yufeng Chen*, Shini Liu2, Jinghong Chen2, Zihuan Yang3, Jianfeng Chen2, Xinjuan Fan4, Peili Wang2, Zerong Cai1, Yali Wang2, Peishan Hu3, Dezheng Lin5, Rong Xiao6, Yifeng Zou1, Yan Huang4, Qiang Yu, Ping Lan, Jing Tan#, Xiaojian Wu#. Inhibition of the PLK1-coupled cell cycle machinery overcomes resistance to oxaliplatin in colorectal cancer. Advanced Science. 28 October 2021 doi.org/10.1002/advs.202100759 (#qQ T IF16.8) 15. Liu S, Zou Q, Chen JP, Yao X, Guan P, Liang W, Deng P, Lai X, Yin J, Chen J, Chen R, Yu Z, Xiao R, Sun Y, Hong JH, Liu H, Lu H, Chen J, Bei JX, Koh J, Chan JY, Wang B, Kang T, Yu Q, Teh BT, Liu J, Xiong Y, Tan J. Targeting Enhancer Reprogramming to Mitigate MEK Inhibitor Resistance in preclinical models of Advanced Ovarian Cancer. J Clin Invest 2021 Oct 15;131(20):e145035. doi: 10.1172/JCI145035. (\O IF:19.456) 16. Liu L, Liu S, Deng P, Liang Y, Xiao R, Tang LQ, Chen J, Chen QY, Guan P, Yan SM, Huang X, Hong JH, Chen J, Sun Y, Teh BT, Yu Q, Mai HQ, Tan J. Targeting the IRAK1-S100A9 Axis Overcomes Resistance to Paclitaxel in Nasopharyngeal Carcinoma. Cancer Res. 2021 Mar 1;81(5):1413-1425. doi: 10.1158/0008-5472.CAN-20-2125. PMID: 33402387 \O IF:13.5 17. Xing M#, Ooi WF#, Tan J#, Qamra A, Lee PH, Li Z, Xu C, Padmanabhan N, Lim JQ, Guo YA, Yao X, Amit M, Ng LM, Sheng T, Wang J, Huang KK, Anene-Nzelu CG, Ho SWT, Ray M, Ma L, Fazzi G, Lim KJ, Wijaya GC, Zhang S, Nandi T, Yan T, Chang MM, Das K, Isa ZFA, Wu J, Poon PSY, Lam YN, Lin JS, Tay ST, Lee MH, Tan ALK, Ong X, White K, Rozen SG, Beer M, Foo RSY, Grabsch HI, Skanderup AJ, Li S, Teh BT, Tan P.  HYPERLINK "https://www.ncbi.nlm.nih.gov/pubmed/32364535" Genomic and epigenomicEBF1alterations modulate TERT expression in gastric cancer. J Clin Invest. 2020 May 4. pii: 126726. doi: 10.1172/JCI126726 #qQ TN\O IF19.468 18. Nairismgi M, Gerritsen ME, Li ZM, Wijaya GC, Chia BKH, Laurensia Y, Lim JQ, Yeoh KW, Yao XS, Pang WL, Bisconte A, Hill RJ, Bradshaw JM, Huang D, Song TLL, Ng CCY, Rajasegaran V, Tang T, Tang QQ, Xia XJ, Kang TB, Teh BT, Lim ST, Ong CK, Tan J. Oncogenic Activation of JAK3-STAT Signaling Confers Clinical Sensitivity to PRN371, a Novel Selective and Potent JAK3 Inhibitor, in Natural Killer/T-cell Lymphoma  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/?term=JAK-STAT+and+G+protein-coupled+receptor+signaling+pathways+are+frequently+altered+in+epitheliotropic+intestinal+T-cell+lymphoma" \o "Leukemia." Leukemia 2018 Feb 2. doi: 10.1038/s41375-017-0004 . \O IF11.702 bgSlS 10-Y,4T\QR,YOgqN. CDK4/6b6RBRTTeYl)R”(W6RYSuo'`~vLvvluoir-Nv^(u.  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